Single-cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer.

Russell K PachynskiEric H KimNatalia MiheechevaNikita KotlovAkshaya RamachandranEkaterina PostovalovaIlia GalkinViktor SvekolkinYang LyuQiong ZouDengfeng Cao Joseph P Gaut Joseph E Ippolito Alexander V BagaevMaria BruttanOlga GancharovaKrystle NomieMaria TsiperGerald L AndrioleRavshan AtaullakhanovJames J Hsieh

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our study identified distinct molecular, cellular, and structural characteristics associated with mpMRI-visible csPCa, whereas mpMRI-invisible tumors were similar to normal prostate tissue, likely contributing to mpMRI invisibility.

Keyphrases

prostate cancer
single cell
radical prostatectomy
rna seq
magnetic resonance imaging
contrast enhanced
high throughput
benign prostatic hyperplasia
single molecule