HLA-Homozygous iPSC-Derived Mesenchymal Stem Cells Rescue Rotenone-Induced Experimental Leber's Hereditary Optic Neuropathy-like Models In Vitro and In Vivo.
En-Tung TsaiShih-Yuan PengYou-Ren WuTai-Chi LinChih-Ying ChenYu-Hao LiuYu-Hsin TsengYu-Jer HsiaoHuan-Chin TsengWei-Yi LaiYi-Ying LinYi-Ping YangShih-Hwa ChiouShih-Pin ChenYueh ChienPublished in: Cells (2023)
The generation of iMSCs via the HLA homozygosity of iPSCs offers a compelling avenue for overcoming the current limitations of MSC-based therapies. The results underscore the potential of iMSCs when addressing retinal disorders, and they highlight their clinical significance, offering renewed hope for individuals affected by LHON and other inherited retinal conditions.