Molecular and Pathology Features of Colorectal Tumors and Patient Outcomes Are Associated with Fusobacterium nucleatum and Its Subspecies animalis.
Ivan BorozanSyed H ZaidiTabitha A HarrisonAmanda I PhippsJiayin ZhengStephen Dongsoo LeeQuang M TrinhRobert S SteinfelderJeremy AdamsBarbara L BanburySonja I BerndtStefanie BrezinaDaniel D BuchananSusan BullmanYin CaoAlton Brad FarrisJane C FigueiredoMarios GiannakisLawrence E HeislerJohn L HopperYi LinXuemei LuoReiko NishiharaElaine R MardisNickolas PapadopoulosConghui QuEmma E G ReidStephen N ThibodeauSophia HarlidCaroline Y UmLi HsuAndrea GsurPeter T CampbellSteven GallingerPolly A NewcombShuji OginoWei SunThomas J HudsonVincent FerrettiUlrike PetersPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2021)
Our findings identify the F. nucleatum subspecies animalis as negatively impacting colorectal cancer mortality, which may occur through a stage shift and its effect on chemoresistance.