Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection.

Shuhei KosonoAkihiro KasaiSumika KomabaTeruhiko MatsubaraToshinori SatoDaisuke Takahashi Kazunobu Toshima

Published in: Chemical communications (Cambridge, England) (2018)

Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

Keyphrases

induced apoptosis
high throughput
endoplasmic reticulum stress
cell proliferation
binding protein
dna binding