IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ~1,500 Samples.
Theresa KisselLise HafkenscheidTineke J WesemaelMami TamaiShin-Ya KawashiriAtsushi KawakamiHani S El-GabalawyDirkjan van SchaardenburgSolbritt Rantapää DahlqvistManfred WuhrerAnnette H M van der Helm-van MilCornelia F AllaartDiane van der WoudeHans Ulrich SchererRene E M ToesTom W J HuizingaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
The abundance of IgG ACPA VDG increases toward RA onset and correlates with maturation of the ACPA response. While IgG ACPA VDG levels are fairly stable in established disease, a lower degree of VDG at RA onset correlates with DFR. Although the underlying biologic mechanisms remain elusive, our data support the concept that VDG relates to an expansion of the ACPA response in the pre-disease phase and contributes to disease development.