The neurodevelopmental transcriptome of the Drosophila melanogaster microcephaly gene abnormal spindle reveals a role for temporal transcription factors and the immune system in regulating brain size.
Maria C ManninoMercedes Bartels CassidySteven FlorezZeid RusanShalini ChakrabortyTodd A SchoborgPublished in: bioRxiv : the preprint server for biology (2023)
mutants. Our results add to the growing number of pathways necessary for brain growth control, and provide a suitable foundation for follow-up genetic studies to assess MCPH.
Keyphrases
- drosophila melanogaster
- genome wide
- resting state
- white matter
- transcription factor
- zika virus
- copy number
- functional connectivity
- gene expression
- cerebral ischemia
- intellectual disability
- dna methylation
- genome wide identification
- single cell
- autism spectrum disorder
- brain injury
- dna binding
- blood brain barrier
- congenital heart disease