Sex dimorphisms in coagulation: Implications in trauma-induced coagulopathy and trauma resuscitation.
Julia R ColemanRichard GuminaThomas HundMitchell CohenMatthew D NealKristy TownsendBryce A KerlinPublished in: American journal of hematology (2024)
Trauma-induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrates a strong sex-dependent effect. Females exhibit a relative hypercoagulability compared to males, which persists after injury and confers improved outcomes. The mechanisms underlying sex dimorphisms in coagulation and its protective effect after injury have yet to be elucidated. This review explores sex dimorphisms in enzymatic hemostasis, fibrinogen, platelets, and fibrinolysis, with implications for resuscitation of patients with TIC.
Keyphrases
- obsessive compulsive disorder
- cardiac arrest
- end stage renal disease
- high glucose
- diabetic rats
- ejection fraction
- trauma patients
- chronic kidney disease
- prognostic factors
- drug induced
- cardiovascular events
- cardiopulmonary resuscitation
- cardiovascular disease
- peritoneal dialysis
- hydrogen peroxide
- coronary artery disease
- septic shock
- metabolic syndrome
- patient reported outcomes
- patient reported