TLR7 mediates increased vulnerability to ischemic acute kidney injury in diabetes.
Huang YayiFang ZhouYe Da XiaoCheng ShenKang LiuZhao BoPublished in: Revista da Associacao Medica Brasileira (1992) (2019)
Our results suggest that diabetes increases the vulnerability to ischemia-induced renal injury. This increased vulnerability originates from a heightened inflammatory response involving the TLR7 signal transduction pathway.
Keyphrases
- inflammatory response
- climate change
- toll like receptor
- type diabetes
- lipopolysaccharide induced
- cardiovascular disease
- glycemic control
- lps induced
- immune response
- high glucose
- diabetic rats
- ischemia reperfusion injury
- metabolic syndrome
- oxidative stress
- brain injury
- skeletal muscle
- endothelial cells
- subarachnoid hemorrhage