Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat subinhibitory concentrations.
Sha LiuYin ZhaoAndrew HayesKaren HonGuimin ZhangCatherine BennettHua HuJohn FinnieSandra MoralesLinda ShearwinAlkis J PsaltisKeith ShearwinPeter-John WormaldSarah VreugdePublished in: Allergy (2021)
Subinhibitory concentrations of PSI antibiotics could sensitize phage-resistant S. aureus and MRSA strains to phages in vitro and in vivo. This data supports the potential use of phage-PSI antibiotic combination therapies, in particular for difficult-to-treat infections with phage-resistant S. aureus and MRSA strains.