Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant.
Adeline Yi Ling LimAdrian Christian MattkeJulia Elizabeth ClarkAlberto Pinzon-CharryNelson AlphonsoNitin KapurPublished in: Case reports in pediatrics (2020)
Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy. The infant required cardiorespiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. This case highlights the potential for severe acquired immunodeficiency in this patient cohort and further postnatal surveillance is highly recommended.
Keyphrases
- extracorporeal membrane oxygenation
- respiratory failure
- acute respiratory distress syndrome
- early onset
- mechanical ventilation
- end stage renal disease
- pregnancy outcomes
- public health
- ejection fraction
- newly diagnosed
- drug induced
- preterm infants
- intensive care unit
- squamous cell carcinoma
- case report
- birth weight
- candida albicans
- chemotherapy induced