A coassembled peptide hydrogel boosts the radiosensitization of cisplatin.

Qian WangXiaoxue HouJie GaoChunhua RenQingxiang GuoHuirong FanJinjian LiuWenxue ZhangJianfeng Liu

Published in: Chemical communications (Cambridge, England) (2021)

We constructed a novel supramolecular hydrogel by carrying out a coassembly of cisplatin and short naproxen-capped peptides. This procedure boosted the radiosensitization effect of cisplatin by increasing the number of Pt-DNA adducts, arresting the cell cycle, and inhibiting cyclooxygenase-2.

Keyphrases

cell cycle
drug delivery
cell proliferation
hyaluronic acid
wound healing
signaling pathway
wastewater treatment
tissue engineering
circulating tumor
minimally invasive
energy transfer