Systemic translocation of Staphylococcus drives autoantibody production in HIV disease.
Zhenwu LuoMin LiYongxia WuZhefeng MengLisa MartinLumin ZhangElizabeth OgunrindeZejun ZhouShenghui QinZhuang WanMaria Anna Julia WesterinkStephanie WarthHui LiuPing JinDavid StroncekQuan-Zhen LiEna WangXueling WuSonya L HeathZihai LiAlexander V AlekseyenkoWei JiangPublished in: Microbiome (2019)
Our results showed that translocation of Staphylococcus can promote B cell activation through enhancing germinal center response and induces autoantibody production. It uncovers a potential mechanism linking microbial translocation and autoimmunity in HIV+ disease and provides a strong rationale for targeting Staphylococcus to prevent autoantibody production.