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Pharmacological Effects and Clinical Prospects of Cepharanthine.

Di LiangQi LiLina DuGuifang Dou
Published in: Molecules (Basel, Switzerland) (2022)
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral effects. Following the emergence of coronavirus disease 2019 (COVID-19), cepharanthine has been found to have excellent anti-COVID-19 activity. In this review, the important physicochemical properties and pharmacological effects of cepharanthine, particularly the antiviral effect, are systematically described. Additionally, the molecular mechanisms and novel dosage formulations for the efficient, safe, and convenient delivery of cepharanthine are summarized.
Keyphrases
  • coronavirus disease
  • anti inflammatory
  • sars cov
  • respiratory syndrome coronavirus
  • oxidative stress