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Clinical characteristics and outcomes in adult cystic fibrosis patients with severe lung disease in Porto Alegre, southern Brazil.

Guilherme Figueiredo SilvaNicholas J SimmondsPaulo de Tarso Roth Dalcin
Published in: BMC pulmonary medicine (2020)
Median survival of CF subjects with FEV1 < 30% was 37 months. BMI and tobramycin inhalation therapy were independently associated with death. Median survival in patients with BMI < 18.5 kg/m2 was significantly lower than in patients with BMI ≥ 18.5 kg/m2. The association of tobramycin inhalation with death was interpreted as confounding by severity (use was reserved for advanced lung disease).
Keyphrases
  • cystic fibrosis
  • body mass index
  • weight gain
  • pseudomonas aeruginosa
  • free survival
  • lung function
  • early onset
  • stem cells
  • physical activity
  • adipose tissue
  • mesenchymal stem cells
  • cell therapy
  • smoking cessation