Toll-like receptor 7 agonist, GS-986, is an immune-stimulant inducing follicular helper T cells and expanding HBs antigen-specific B cells in vitro.

Taizo Mori Sachiyo YoshioShiori YoshikawaYuriko TsustuiToshihiro SakataYuichi YoshidaYuzuru SakamotoHironari KawaiYosuke OsawaTaiji YamazoeYoshihiko AokiSimon P FletcherTatsuya Kanto

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

GS-986 is an adjuvant that stimulates pDCs to induce Tfh differentiation and antigen-specific B-cell production. This immune profile may be beneficial for therapeutic application as an immune modulator in CHB patients.

Keyphrases

toll like receptor
end stage renal disease
inflammatory response
ejection fraction
newly diagnosed
nuclear factor
immune response
early stage
chronic kidney disease
peritoneal dialysis
prognostic factors
attention deficit hyperactivity disorder
regulatory t cells
patient reported