Toll-like receptor 7 agonist, GS-986, is an immune-stimulant inducing follicular helper T cells and expanding HBs antigen-specific B cells in vitro.
Taizo MoriSachiyo YoshioShiori YoshikawaYuriko TsustuiToshihiro SakataYuichi YoshidaYuzuru SakamotoHironari KawaiYosuke OsawaTaiji YamazoeYoshihiko AokiSimon P FletcherTatsuya KantoPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
GS-986 is an adjuvant that stimulates pDCs to induce Tfh differentiation and antigen-specific B-cell production. This immune profile may be beneficial for therapeutic application as an immune modulator in CHB patients.