Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI.
Bridget A KennisKeith A MichelWilliam B BrugmannAlvaro LaureanoRong-Hua TaoSrinivas S SomanchiSamuel A EinsteinJaviera B Bravo-AlegriaShinji MaegawaAndrew WahbaSimin KianyNancy GordonLucia SillaDawid SchellingerhoutSoumen KhatuaWafik ZakyDavid SandbergLaurence CooperDean A LeeJames A BanksonVidya GopalakrishnanPublished in: Journal of neuro-oncology (2019)
Our results show that NK cells present a novel opportunity for new strategies in MB treatment. Further, 19F-labeled NK cells can suppress MB growth while enabling 19F MRI to provide imaging feedback that can facilitate study and optimization of therapeutic paradigms.