Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1).
Yun Shan GohSiew-Wai FongPei Xiang HorChiew Yee LohMatthew Zirui TayBei WangSiti Nazihah Mohd SallehEve Zi Xian NgohRaphael Tze Chuen LeeXuan Ying PohI Russel LeeSuma RaoPo Ying Chianull nullSebastian Maurer-StrohCheng-I WangYee-Sin LeoDavid C LyeBarnaby Edward YoungLisa F P NgLaurent ReniaPublished in: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2024)
The findings suggest imprinting of antibody responses that is shaped by the first vaccination (WT spike). Previous infection also affects the boosting effect of follow-up vaccination. Studies are needed to understand how to induce a robust and long-lasting IgA immunity for protection against COVID-19 infection.
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