Plasma Adrenomedullin, Allelic Variations in the ADM Gene, and Risk for Lower-Limb Amputation in People With Type 2 Diabetes.

Louis PotierKamel MohammediPierre-Jean SaulnierFrédéric FumeronJean-Michel HalimiNicolas VenteclefMichel MarreSamy HadjadjRonan RousselGilberto Velho

Published in: Diabetes care (2022)

We observed associations of plasma MR-proADM with LLA and of ADM SNPs with plasma MR-proADM and with LLA in people with type 2 diabetes. This pattern of Mendelian randomization supports the causality of the association of ADM with LLA.

Keyphrases

lower limb
genome wide
magnetic resonance
contrast enhanced
magnetic resonance imaging
emergency department
gene expression
adverse drug
transcription factor
peripheral artery disease
genome wide identification