Targeting N4-acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2-mediated HMGB2 mRNA translation.

Hailing LiuLei XuShiwei Yue Hongfei SuXing ChenQiumeng LiuHui LiHui-Fang LiangXiaoping ChenJiefeng HeZeyang DingBixiang Zhang

Published in: Cancer communications (London, England) (2024)

Our study identified a novel oncogenic epi-transcriptome axis involving NAT10-ac4C/eEF2-HMGB2, which plays a pivotal role in regulating HCC growth and metastasis. The drug Panobinostat validates the therapeutic potential of targeting this axis for HCC treatment.

Keyphrases

cancer therapy
gene expression
signaling pathway
transcription factor
genome wide
single cell
emergency department
histone deacetylase
drug induced