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Child with tuberculous meningitis and COVID-19 coinfection complicated by extensive cerebral sinus venous thrombosis.

Farida EssajeeRegan S SolomonsSavvas AndronikouRonald Van Toorn
Published in: BMJ case reports (2020)
We herein report a case of a child with tuberculous meningitis and COVID-19 coinfection complicated by hydrocephalus, arterial ischaemic stroke and extensive cerebral sinus venous thrombosis. Both conditions induce a proinflammatory cytokine drive resulting, among others, in a prothrombotic state. The disruption of the coagulation system in this case was supported by elevated D-dimers, fibrinogen and ferritin levels, consistent with thrombotic complications reported in some adult patients infected with COVID-19. The child also exhibited prolonged viral shedding that suggests severe disease.
Keyphrases
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  • coronavirus disease
  • subarachnoid hemorrhage
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  • cerebrospinal fluid
  • respiratory syndrome coronavirus
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  • blood brain barrier
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