Impact of overweight and obesity on the risk of hepatocellular carcinoma: a prospective cohort study in 14.3 million Koreans.

Baek Gyu JunMoonho KimHwang Sik ShinJee-Jeon YiSang-Wook Yi

Published in: British journal of cancer (2022)

Overweight and obesity clearly increase HCC risk in Koreans. ALT levels are a mediator of the impact of obesity, but it may not accurately predict high BMI-induced liver damage that can potentially progress to HCC, especially in women and older adults.

Keyphrases

weight gain
insulin resistance
polycystic ovary syndrome
metabolic syndrome
high glucose
diabetic rats
oxidative stress
body mass index
physical activity
weight loss
type diabetes
pregnancy outcomes
breast cancer risk
high fat diet induced
drug induced
pregnant women
adipose tissue
endothelial cells