Noninvasive assessment of autonomic modulation of heart rate variability in the Ts65Dn mouse model of Down syndrome: A proof of principle study.
Adriano L RoqueMark W JohnsonMelissa R StaskoLuiz C de AbreuTalita D da SilvaAlberto C S CostaPublished in: Physiological reports (2021)
This work showed that the techniques described here are sufficient for this type of study. However, future studies involving the use of more selective pharmacological agents and/or genetic manipulations will be key to advance a mechanistic understanding of cardiac autonomic regulation in DS.