Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex.
Louisa M SalemiMatthew E R MaitlandEyal R YefetCaroline Schild-PoulterPublished in: BMC cancer (2017)
Our work shows that RanBPM, together with the CTLH complex, associates with HDAC6 and restricts cell migration through inhibition of HDAC6 activity. This study uncovers a novel function for the CTLH complex and suggests that it could have a tumour suppressive role in restricting HDAC6 oncogenic properties.