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Rhodium-catalyzed C-H carboxymethylation of anilines with vinylene carbonate.

Qiong LiuZhaolong MaJing ZhangXu-Qin Li
Published in: Organic & biomolecular chemistry (2023)
A rhodium-catalyzed synthesis of phenylacetate has been realized by direct C-H carboxymethylation of anilines bearing removable directing groups. The reaction occurred most efficiently in air, without any external base or oxidant. This methodology is expected to provide a facile and general access to various bioactive 2-amino aromatic acetic acid derivatives.
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