In vivo animal models confirm an increased virulence potential and pathogenicity of the NAP1/RT027/ST01 genotype within the Clostridium difficile MLST Clade 2.
Josué Orozco-AguilarAlejandro Alfaro-AlarcónLuis Acuña-AmadorEsteban Chaves-OlarteCésar RodríguezCarlos Quesada-GómezPublished in: Gut pathogens (2020)
Despite their close phylogenic relatedness, our results demonstrate differences in pathogenicity and virulence levels in Clade 2 C. difficile strains, confirm the high severity of infections caused by the NAP1/RT027/ST01 strain, and highlight the importance of C. difficile typing.