Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA.

Kristin SchmiedebergIrene A AbelaNatalia Barbara PikorNicolas VuilleumierMagdalena SchwarzmuellerSelina EppSabrina PaganoSarah GrabherrAngelica Brooke PattersonMadalina NussbergerAlexandra TrkolaBurkhard LudewigJohannes von KempisAndrea Rubbert-Roth

Published in: RMD open (2022)

In patients with RA, vaccine-induced IgG antibody levels were diminished, while IgA and IgM responses persisted, indicating a delayed isotype switch. Anti-S IgG levels 2 weeks after the second vaccine dose correlate with the development of a potent neutralising activity after 12 and 24 weeks and may allow to identify patients who might benefit from additional vaccine doses or prophylactic regimen.

Keyphrases

sars cov
rheumatoid arthritis
gestational age
disease activity
oxidative stress
systemic lupus erythematosus
ankylosing spondylitis
drug induced
interstitial lung disease
anti inflammatory