Methylglyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells.
Hee-Weon LeeMin Ji GuJee-Young LeeSeungju LeeYoonsook KimSang-Keun HaPublished in: Molecular nutrition & food research (2021)
MOLD plays a major role in nephropathy via ROS production and mitochondrial dysfunction through direct association with RAGE. Further, the NF-kB and PI3K/AKT signaling pathways triggered by ROS mediate the inflammatory response to exacerbate MOLD-induced damages in inflammation-related diabetic and non-diabetic renal diseases.
Keyphrases
- pi k akt
- cell cycle arrest
- signaling pathway
- oxidative stress
- induced apoptosis
- cell death
- diabetic rats
- high glucose
- dna damage
- cell proliferation
- type diabetes
- reactive oxygen species
- wound healing
- endothelial cells
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- diabetic nephropathy
- inflammatory response