Genome-wide analysis to assess if heavy alcohol consumption modifies the association between SNPs and pancreatic cancer risk.
Zhanmo NiProsenjit KunduDavid F McKeanWilliam WheelerDemetrios AlbanesGabriella AndreottiSamuel O AntwiAlan A ArslanWilliam R BamletLaura E Beane-FreemanSonja I BerndtPaige M BracciPaul J BrennanJulie E BuringStephen J ChanockSteven J GallingerJohn Michael GazianoGraham G GilesEdward L GiovannucciMichael G GogginsPhyllis J GoodmanChristopher A HaimanManal M HassanElizabeth A HollyRayjean J HungVerena A KatzkeCharles KooperbergPeter KraftLoic Le MarchandDounghui LiMarjorie L McCulloughJonathan BeesleySteven C MooreRachel E NealeAnn L ObergAlpa V PatelUlrike PetersKari G RabeHarvey A RischChristina E BaileyKarl Smith ByrneKala VisvanathanJean Wactawski-WendeEmily WhiteBrian M WolpinHerbert YuAnne Zeleniuch-JacquotteQuan LongJun ZhongLaufey T AmundadottirRachael Z Stolzenberg-SolomonAlison P KleinPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2024)
We identified a novel genomic region that may be associated with pancreatic cancer risk in conjunction with heavy alcohol consumption located near an eQTL for the NRP1, a protein that plays an important role in the development and progression of pancreatic cancer Impact: This work can provide insight into the etiology of pancreatic cancer particularly in heavy drinkers.