Delivery of Platinum(IV) Prodrugs via Bi2Te3 Nanoparticles for Photothermal-Chemotherapy and Photothermal/Photoacoustic Imaging.
Yan MaDong-Yang ZhangZhuo PengShixia GuanJunqiu ZhaiPublished in: Molecular pharmaceutics (2020)
Combinational administration of photothermal therapy (PTT) and chemotherapy (CT) shows great potential in improving the efficiency of tumor treatment. Herein, we designed a novel nanocomposite Pt@Bi2Te3 composed of bismuth telluride (Bi2Te3) nanoparticles and platinum(IV) prodrugs (Pt) for PTT-CT combination therapy. The obtained Bi2Te3 was synthesized by a simple solvothermal method and modified by polyethylene glycol, which exhibited excellent photothermal (PT) efficiency and stability and could also serve as a bimodal bioimaging contrast agent in PT and photoacoustic (PA) imaging. In vitro experiment results showed that the nanocomposite Pt@Bi2Te3 could effectively increase the uptake of platinum in cancer cells, which could kill tumor cells through the combined effect of PTT and CT. Furthermore, combination therapy of cancer in vivo was achieved with obvious tumor-growth inhibition without inducing observed side effects. We revealed the great potential of Bi2Te3 nanocomposites in increasing therapeutic efficiency by PTT-CT therapy and PA-PT imaging.
Keyphrases
- combination therapy
- contrast enhanced
- image quality
- dual energy
- computed tomography
- high resolution
- photodynamic therapy
- fluorescence imaging
- cancer therapy
- drug delivery
- reduced graphene oxide
- quantum dots
- positron emission tomography
- magnetic resonance imaging
- magnetic resonance
- drug release
- carbon nanotubes
- stem cells
- risk assessment
- human health
- mass spectrometry
- mesenchymal stem cells
- replacement therapy
- radiation therapy
- cell therapy