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Pharmacogenetic Association between Allelic Variants of the Autophagy-Related Genes and Anti-Vascular Endothelial Growth Factor Treatment Response in Neovascular Age-Related Macular Degeneration.

Oyuna S KozhevnikovaAnzhella Zh FursovaAnna S DerbenevaIda F NikulichVasiliy A DevyatkinNataliya G Kolosova
Published in: Biomedicines (2023)
-rs3088051 may influence short-term response to intravitreal anti-VEGF treatment. The results suggest that autophagy could be a target for future drugs to overcome resistance to anti-VEGF therapy.
Keyphrases
  • vascular endothelial growth factor
  • age related macular degeneration
  • endothelial cells
  • cell death
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • stem cells
  • gene expression
  • diabetic retinopathy