Self-Assembly of Novel Thiophene-Based BODIPY RuII Rectangles: Potential Antiproliferative Agents Selective Against Cancer Cells.

Gajendra Gupta Abhishek DasSourav PanjaJi Yeon RyuJunseong LeeNripendranath MandalChang Yeon Lee

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2017)

Novel Ru (2+2) rectangles were designed and synthesized by self-assembly of a new thiophene-functionalized dipyridyl BODIPY ligand, BDPS, and ruthenium(II) precursors. The complexes exhibited dose-dependent antiproliferative activities against cancer cells, in which some compounds selectively kill cancer cells. The net fluorescence due to BODIPY allowed us to visualize their location inside cancer cells. Moreover, the metalla-rectangles displayed substantial propensity to bind with biomolecules.

Keyphrases

fluorescent probe
living cells
single molecule
energy transfer
quantum dots
mass spectrometry
human health