Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation.
Claudia Marcela ChalelaAngela Maria PeñaAngela Maria RoaDavid L ReyesJennifer Paola RuedaLuis Antonio SalazarManuel RosalesEdgar David GomezEdgar Augusto BernalClaudia Lucia Sossa MeloPublished in: Revista da Sociedade Brasileira de Medicina Tropical (2020)
Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
Keyphrases
- trypanosoma cruzi
- stem cell transplantation
- drug induced
- hodgkin lymphoma
- liver injury
- newly diagnosed
- cell therapy
- end stage renal disease
- high dose
- case report
- ejection fraction
- chronic kidney disease
- nk cells
- bone marrow
- acute myeloid leukemia
- prognostic factors
- peritoneal dialysis
- low dose
- stem cells
- patient reported outcomes