A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017.

Yuta AwanoRyoya IshiiYume TakahashiHayama TsutsumiYoshihiro WatanabeMasaaki SonodaRei HokariMasato Iwatsuki Yuki Inahashi

Published in: The Journal of antibiotics (2024)

A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.

Keyphrases

candida albicans
biofilm formation
high resolution
mass spectrometry
magnetic resonance
multiple sclerosis
ms ms
solid state
escherichia coli