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Has GWAS lost its status as a paragon of open science?

Callie H BurtMarcus R Munafo
Published in: PLoS biology (2021)
Genomic research led the way in open science, a tradition continued by genome-wide association studies (GWAS)-through the sharing of materials, results, and data. Coordinated quality control procedures also contributed to robust findings. However, recent years have seen declines in GWAS transparency. Here, we assess some shifts away from open science practices with the aim of stimulating a discussion of these issues.
Keyphrases
  • quality control
  • minimally invasive
  • public health
  • genome wide association
  • primary care
  • healthcare
  • copy number
  • gene expression
  • machine learning
  • genome wide association study
  • dna methylation
  • artificial intelligence