Pathogenic bacteria in daily life, such as Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), often seriously affect human life and health. The extensive use of antibiotics has led to the emergence of drug-resistant bacteria, so it is urgent to develop efficient and non-drug-resistant sterilization methods. Here, we use small-molecule cysteine (Cys) as an auxiliary agent to synthesize spherical porous amorphous CuS-Cysteine (CuS-C) nanoparticles, which have good dispersion in aqueous solutions, and explore the reaction mechanism of Cys-induced CuS synthesis. The synthesized composite nanomaterials have strong near-infrared light absorption ability and efficient photothermal conversion ability and can effectively ablate pathogenic bacteria under the irradiation of an 808 nm laser. In addition, antibacterial experiments showed that CuS-C composites had no bactericidal effect without near-infrared light, but they had a good photothermal bactericidal effect on S. aureus and E. coli under radiation conditions. Considering the simple synthesis process, strong photothermal conversion ability, low cost, and suitability for large-scale production, CuS-C nanocomposites, as a promising antibacterial material, will provide a feasible scheme for the treatment of drug-resistant pathogens.
Keyphrases
- drug resistant
- photodynamic therapy
- escherichia coli
- multidrug resistant
- cancer therapy
- acinetobacter baumannii
- small molecule
- low cost
- drug delivery
- drug release
- staphylococcus aureus
- silver nanoparticles
- gram negative
- amino acid
- healthcare
- public health
- endothelial cells
- klebsiella pneumoniae
- physical activity
- reduced graphene oxide
- anti inflammatory
- oxidative stress
- combination therapy
- fluorescent probe
- health information
- induced pluripotent stem cells
- visible light
- high speed
- risk assessment
- radiation therapy
- high resolution
- methicillin resistant staphylococcus aureus
- metal organic framework
- highly efficient
- smoking cessation
- ionic liquid
- oxide nanoparticles