Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic-ischemic injury in rats.

Shucai XieXili JiangDesislava Met DoychevaHui ShiPeng JinLing GaoRui LiuJie XiaoXiao HuJiping TangLina ZhangArne P Neyrinck

Published in: Journal of neuroinflammation (2021)

TC-G 1008 attenuated neuroinflammation in part via the SIRT1/PGC-1α/Nrf2 pathway in a neonatal rat model of HIE. TC-G 1008 may be a novel therapeutic target for treatment post-neonatal HIE injury.

Keyphrases

oxidative stress
skeletal muscle
traumatic brain injury
lipopolysaccharide induced
lps induced
ischemia reperfusion injury
cognitive impairment
brain injury
smoking cessation
blood brain barrier
subarachnoid hemorrhage