The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension.
Lance N BensonYunmeng LiuXiangting WangYunzhao XiongSung W RheeYunping GuoKatherine S DeckChristoph J MoraLin-Xi LiLu HuangJ Tucker AndrewsZhiqiang QinRobert S HooverBenjamin KoRyan M WilliamsDaniel A HellerEdgar A JaimesShengyu MuPublished in: Circulation research (2022)
Our results identified the role of activated CD8Ts in contributing to increased sodium retention in DCTS through the IFNγ-PDL1 pathway. These findings provide a new mechanism for T cell involvement in the pathogenesis of hypertension and reveal novel therapeutic targets.