Are working memory and glutamate concentrations involved in early-life stress and severity of psychosis?

Mark CorcoranEmma L HawkinsDenis O'HoraHeather C WhalleyJeremy HallStephen M LawrieMaria Regina Dauvermann

Published in: Brain and behavior (2020)

In individuals with PSY, the current study found no evidence that the association between ELS and psychotic symptoms is mediated by WM performance or prefrontal glutamate concentrations. In HC, the association between ELS experience and glutamate concentrations may indicate a neurometabolite effect of ELS that is independent of an illness effect in psychosis.

Keyphrases

working memory
early life
transcranial direct current stimulation
attention deficit hyperactivity disorder
bipolar disorder
sleep quality
functional connectivity
stress induced