Comparisons of Metabolic Measures to Predict T1D vs. Detect a Preventive Treatment Effect in High-Risk Individuals.
Emily K SimsDavid CuthbertsonLaura JacobsenHeba M IsmailBrandon M NathanKevan C HeroldMaria J RedondoJay SosenkoPublished in: The Journal of clinical endocrinology and metabolism (2024)
The capacity of a metabolic endpoint to detect a treatment effect does not necessarily correspond to its accuracy for predicting T1D. However, combined glucose and C-peptide endpoints appear to be effective for both predicting diabetes and detecting a response to immunotherapy. These findings suggest that combined glucose and C-peptide endpoints should be incorporated into the design of future T1D prevention trials.