PNPLA3 rs738409 and risk of fibrosis in NAFLD: Exploring mediation pathways through intermediate histological features.
Eduardo Vilar-GomezCarlos Jose PirolaSilvia SookoianLaura A WilsonTiebing LiangNaga P ChalasaniPublished in: Hepatology (Baltimore, Md.) (2022)
In NAFLD, nearly half of the total effect of the rs738409 G allele on fibrosis severity could be explained by a direct pathway, suggesting that rs738409 may promote fibrosis development by activating specific fibrogenic pathways. A large proportion of the indirect effect of rs738409 on fibrosis severity is mediated through portal inflammation.