Association between TPMT*3C and decreased thiopurine S-methyltransferase activity in patients with neuromyelitis optica spectrum disorders in China.

Xiaoqing GongShenghui MeiXindi LiXingang LiHeng ZhouYonghong LiuAnna ZhouLi YangZhigang ZhaoXinghu Zhang

Published in: The International journal of neuroscience (2017)

TPRs = thiopurines; NMOSD = neuromyelitis optica spectrum disorders; TPMT = thiopurine S-methyltransferase; LC-MS/MS = liquid chromatography tandem mass/mass; 6-MMP = 6-methylmercaptopurine; IS = internal standard; SNP = single nucleotide polymorphism; MAF = minor allele frequency; HWE = Hardy-Weinberg equilibrium; BETA = regression coefficients; UTR-3 = untranslated region 3.

Keyphrases

liquid chromatography
mass spectrometry
genome wide
high resolution mass spectrometry
molecular dynamics
tandem mass spectrometry
molecular dynamics simulations
simultaneous determination
cell migration
gene expression
high resolution