MicroRNA-206 enhances antitumor immunity by disrupting the communication between malignant hepatocytes and regulatory T cells in c-Myc mice.
Ningning LiuClifford J SteerGuisheng SongPublished in: Hepatology (Baltimore, Md.) (2021)
c-Myc-educated hepatocytes promoted immunosuppression by overproducing TGFβ1, which promoted HCC development. miR-206, by attenuating TGFβ1 overproduction, disrupted the communication of malignant hepatocytes with CTLs and Tregs, which prevented HCC. miR-206 represents a potential immunotherapeutic agent against HCC.
Keyphrases
- regulatory t cells
- cell proliferation
- long non coding rna
- liver injury
- transforming growth factor
- long noncoding rna
- dendritic cells
- drug induced
- high fat diet induced
- type diabetes
- epithelial mesenchymal transition
- resting state
- signaling pathway
- metabolic syndrome
- skeletal muscle
- functional connectivity
- wild type