Single-cell Profiles and Prognostic Impact of Tumor-Infiltrating Lymphocytes Coexpressing CD39, CD103, and PD-1 in Ovarian Cancer.

Céline M LaumontMaartje C A WoutersJulian SmazynskiNicole S GiercElizabeth A ChavezLauren C ChongShelby ThorntonKaty MilneJohn R WebbChristian SteidlBrad H Nelson

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Coexpression of CD39, CD103, and PD-1 demarcates highly activated CD8+ and CD4+ TIL with inferred roles in cytolytic, humoral, and regulatory immune functions. Triple-positive TIL demonstrate exceptional prognostic significance and express compelling targets for combination immunotherapy, including PD-1, CD39, and TIGIT.

Keyphrases

single cell
immune response
nk cells
rna seq
high throughput