Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate.
Durga M S H ChandrupatlaGerrit JansenElise MantelPhilip S LowTakami MatsuyamaRené P MustersAlbert D WindhorstAdriaan A LammertsmaCarla F M MolthoffConny J van der LakenPublished in: Contrast media & molecular imaging (2018)
MTX treatment reduced activated macrophages in liver and spleen, as markers for systemic inflammation in these organs. Macrophage PET imaging with [18F]fluoro-PEG-folate holds promise for detection of systemic inflammation in RA as well as therapy (MTX) response monitoring.