Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancer.
Shogo TakeiYosuke TanakaYi-Tzu LinSyohei KoyamaShota FukuokaHiroki HaraYoshiaki NakamuraYasutoshi KubokiDaisuke KotaniTakashi KojimaHideaki BandoSaori MishimaToshihide UenoShinya KojimaMasashi WakabayashiNaoya SakamotoMotohiro KojimaTakeshi KuwataTakayuki YoshinoHiroyoshi NishikawaHiroyuki ManoItaru EndoKohei ShitaraAkihito KawazoePublished in: Journal for immunotherapy of cancer (2024)
We identified molecular features associated with the response to the REGONIVO and TASNIVO, particularly those related to tumor microenvironmental factors. These findings are likely to contribute to the development of biomarkers to predict treatment efficacy for MSS/pMMR CRC and future immunotherapy combinations for treatment.