CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation.

He FangAna R TroncoGiancarlo BonoraTruong NguyenJitendra ThakurJoel B BerletchGalina N FilippovaSteven HenikoffJay ShendureWilliam S NobleChristine M DistecheXinxian Deng

Published in: bioRxiv : the preprint server for biology (2023)

Our findings indicate that escape from XCI is modulated both by looping and insulation of chromatin via convergent arrays of CTCF binding sites and by compaction and epigenetic features of the surrounding heterochromatin.

Keyphrases

gene expression
dna damage
transcription factor
genome wide
dna methylation