Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway.
Yijing ZhaoChanghong HeShaozhen HuHaojie NiXiaoqin TanYingkun ZhiLang YiRisong NaYanwu LiQun DuQing X LiYan DongPublished in: Experimental neurology (2024)
TFGF-18 protects against neuronal cell damage and cognitive impairment by inhibiting oxidative stress via AKT/GSK-3β/Nrf2 pathway.
Keyphrases
- oxidative stress
- signaling pathway
- diabetic rats
- pi k akt
- induced apoptosis
- cognitive impairment
- dna damage
- ischemia reperfusion injury
- single cell
- cell proliferation
- cell therapy
- stem cells
- high glucose
- type diabetes
- metabolic syndrome
- adipose tissue
- brain injury
- high fat diet induced
- heat shock
- endoplasmic reticulum stress
- heat shock protein
- subarachnoid hemorrhage
- heat stress