Myocardial Hypertrophy and Fibrosis Are Associated with Cardiomyocyte Beta-Catenin and TRPC6/Calcineurin/NFAT Signaling in Spontaneously Hypertensive Rats with 5/6 Nephrectomy.
Evdokia BogdanovaOlga BeresnevaOlga GalkinaIrina ZubinaGalina IvanovaMarina ParastaevaNatalia Yuryevna SemenovaVladimir DobronravovPublished in: International journal of molecular sciences (2021)
The Wnt/β-catenin and TRPC6/CaN/NFAT hypertrophic signaling pathways seem to be involved in myocardial remodeling in the settings of AH and CKD and might be mediated by FGF23 and α-Klotho axis.
Keyphrases
- cell proliferation
- epithelial mesenchymal transition
- left ventricular
- signaling pathway
- vascular smooth muscle cells
- nuclear factor
- chronic kidney disease
- angiotensin ii
- pi k akt
- stem cells
- robot assisted
- toll like receptor
- endothelial cells
- inflammatory response
- immune response
- high glucose
- atrial fibrillation
- endoplasmic reticulum stress