Predicting Clinical Outcomes 7-10 Years after Severe Traumatic Brain Injury: Exploring the Prognostic Utility of the IMPACT Lab Model and Cerebrospinal Fluid UCH-L1 and MAP-2.

Adrian M SvingosSteven A RobicsekRonald L HayesKevin K WangClaudia S RobertsonGretchen M BrophyLinda PapaAndrea GabrielliH Julia HannayRussell M BauerShelley C Heaton

Published in: Neurocritical care (2022)

Although preliminary, results suggest that existing prognostic models, including models with incorporation of CSF markers, may be applied to predict outcome of severe TBI years after injury. Continued research is needed examining early predictors of longer-term outcomes following TBI to identify potential targets for clinical trials that could impact long-ranging functional and cognitive outcomes.

Keyphrases

severe traumatic brain injury
cerebrospinal fluid
traumatic brain injury
clinical trial
preterm infants
early onset
metabolic syndrome
risk assessment
drug induced
phase ii
skeletal muscle