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Targeting Caspases 3/6 and Cathepsins L/B May Decrease Laminopathy-Induced Apoptosis in Alzheimer's Disease.

Auob RustamzadehAbbas TafakhoriArmin AriaeiMahdi HeydariMehran Ebrahimi Shah-AbadiFarhad Seif
Published in: Journal of Alzheimer's disease : JAD (2024)
Our findings suggest that lamins A/C, cathepsins B/L, caspase 6, and lamin B2 are associated with laminopathy as potential factors contributing to apoptosis in AD. We propose that simultaneous inhibition of caspases 6 and cathepsins L may decrease the rate of apoptosis triggered by lamin degradation. Nevertheless, further studies are required to confirm these observations due to the lack of in vivo findings.
Keyphrases
  • induced apoptosis
  • endoplasmic reticulum stress
  • oxidative stress
  • cell cycle arrest
  • signaling pathway
  • cell death
  • pi k akt
  • cancer therapy
  • case control
  • cell proliferation
  • risk assessment